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A link between male fertility treatments and birth defects?

Test-tube babies have higher rates of birth defects, and doctors have long wondered: Is it because of certain fertility treatments or infertility itself? A large new study from Australia suggests both may play a role.

Compared to those conceived naturally, babies that resulted from simple IVF, or in vitro fertilization - mixing eggs and sperm in a lab dish - had no greater risk of birth defects once factors such as the mom's age and smoking were taken into account.

However, birth defects were more common if treatment included injecting a single sperm into an egg, which is done in many cases these days, especially if male infertility is involved. About 10 percent of babies born this way had birth defects versus 6 percent of those conceived naturally, the study found.

It could be that the extra jostling of egg and sperm does damage. Or that other problems lurk in the genes of sperm so defective they must be forced to fertilize an egg.

"I don't want to scare people," because the vast majority of babies are born healthy, said the study's leader, Michael Davies of the University of Adelaide in Australia.

Couples could use simple IVF without sperm injection, freeze the embryos and implant only one or two at a time, he said. All of those can cut the chance of a birth defect.

The study was published online Saturday by the New England Journal of Medicine and presented at a fertility conference in Barcelona, Spain. Health agencies in Australia paid for the research.

More than 3.7 million babies are born each year through assisted reproduction. Methods include everything from drugs to coax the ovaries to make eggs to artificial insemination and IVF. Fertility treatments account for about 4 percent of births in Australia and as many as 8 percent of them in Denmark, where costs are widely covered, Davies said.

In the United States, more than 60,000 babies were born in 2009 from 146,000 IVF attempts. About three-quarters of them used ICSI, or intracytoplasmic sperm injection.

ICSI was developed because of male infertility. But half the time, it was not done for that reason but to improve the odds that at least some embryos will be created from an IVF attempt. Many clinics do it in all cases.

IVF costs around $10,000 to $12,000 per attempt and another $2,000 for sperm injection.

Article Source: http://www.diureticspill.com/News/2012/0519/fertility-treatment.html

New study shows promise for analyzing interstitial cystitis/ bladder pain syndrome

Interstitial cystitis, also known as bladder pain syndrome, is a debilitating disease of the urinary bladder. The disease can occur with or without bladder ulcers (called Hunner lesions). Interstitial cystitis is a difficult disease to study because animal models are limited, and human patients cannot ethically be subjected to invasive research procedures.

The researchers' goal was to develop a noninvasive method to analyze the bladder epithelium as objectively and directly as possible. During the study, the researchers used microarray technology to analyze cells shed into the urine as an alternative to bladder biopsies, which require anesthesia and have a small risk of bladder injury.

The results showed that urine cells from patients with Hunner lesions had a distinct gene signature for inflammation, similar to the results from a prior microarray study of bladder biopsies. The study was the first to show this inflammation objectively, but without biopsy, in Hunner lesion patients.

If these preliminary results are validated in future research, they may lead to a noninvasive biomarker for Hunner lesion-interstitial cystitis/bladder pain syndrome, says researcher Eric Blalock, associate professor in the Department of Molecular and Biomedical Pharmacology at the UK College of Medicine.

"A crucial next step will be to determine the stability of this set of biomarkers across larger samples of the population," Blalock said. "And to also see if similar procedures could be used for early diagnosis and intervention in the disease process."

For interstitial cystitis patients without Hunner lesions, the gene signatures were similar to healthy controls.

"This is important in view of the ongoing debate whether the two types of interstitial cystitis really are different disorders," said UK urologist Deborah Erickson. "Prior studies showed the two patient types did have different findings on bladder biopsies. Our findings support the difference, but without the need for biopsy."

The study was published in the February issue of the Journal of Urology and was also selected for post-publication in the Faculty of 1000 (F1000), a global peer review group that identifies and evaluates the most important articles in biology and medical research publications. Selection places a researcher's work in F1000's library of the top 2 percent of published articles in biology and medicine.

Provided by University of Kentucky

Article Source: http://www.diureticspill.com/News/2012/0320/cystitis.html

Testimonial from M. Collins (Fuyan Pill Adhesions Testimonial)

The patients should always have the final word! And we need to listen to their opinions and suggestions. Even thought I had found out many managements to reduce my lower abdominal pain, Lee provided a permanent cure for it. Fuyan Pill has helped me to clear up my dull pain in abdomen which bothered me for nearly 1 year, and started since I had chlamydia infection which was treated. I was told after visiting a doctor that I might have adhesions. I had the pain comes and goes, none occurs while I'm on antibiotics, much came back after I stoped. I tried mugwort stick according to a Korean doctor, which really had helped much, but that improvement was temporary as well. Pain always crashed back in next week. Well, everything just went different after I took Fuyan Pill. Pain decreased and diminished fast in the second course of treatment, even there's little change in the first month, however, it never came back! No pain at all in the third month medication! Lee and her crew do have very special opinion on this disease and have their unique treatment for it.

Article Source: http://global.fuyanpills.com/Testimonials/2012/0313/170.html

Surprising! Three months of Fuyan pill keep the mycoplasma and moderate cervical erosion away

Ms. Huang has been 42 years old, but she had the problem of irregular menstruation for many years. When during the period, she always go with the symptoms of menorrhagia and the color present to be black with blood clots, besides, the menstruation usually up to 10 days and also accompanied by dysmenorrhea. In addition, what embarrassed her most was that she had the yellow vaginal discharge, intercourse pain and abdominal pain after intercourse for years.

At first, she paid no care for it. Until earlier this year, she found that she had menstruation twice a month. And between two menstruations, the brown vaginal discharge always existed. So she had no choice but went to the hospital.

The result of leucorrhea routine examination showed that the cleanliness was Ⅳ, and there were no trichomoniasis or mold. The colposcopy examination revealed the moderate cervical erosion while the pathological examination showed the chronic inflammation. Under the doctor's recommendation, she took the western medicine such as doxycycline and ofloxacin, but the results were not so good, the recheck result was still mycoplasma. Since then, she stopped the treatment, but turned the traditional Chinese medicine for help.

Occasionally, she heard the TCM Fuyan pills, and had a try. During medication, she paid more attention on the board feedback and successful cases on our website, and kept all tips in her mind. Fortunately, she kept a good diet habits and limited the sex life with her husband. After a course of Fuyan pills taking, she obviously found that the amount of vaginal discharge reduces and the color changed into white, and without other obvious abnormalities. She then continued to take a course.

In the second course of treatment, Ms. Huang told us that the intercourse pain and moderate cervical erosion was gone, and menstrual blood clots were no longer black and dysmenorrhea only appeared on the first day of menstruation. She felt thankful for it.

Considering the repeated infection of mycoplasma, especially the cross-infection between husband and wife, we recommended her to consolidate a course of treatment, and urged her had a check in the hospital as well as her husband. After three courses, the mycoplasma was no longer positive. She said that Fuyan pill gave her the new hope for life.

If you don’t know how to do when you get such kind of disease, you can turn Fuyan pill for help. It is the traditional medicine and it will give you an unexpected result.

Article Source: http://global.fuyanpills.com/Testimonials/2014/0325/575.html

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